Adjuvant Chemotherapy: Adjuvant Chemotherapy Include Colorectal

June 2nd | KATZUNG

One of the most important roles for chemotherapy is effective against cancer as an adjuvant to initial therapy or primary domain with other methods such as surgery or radiotherapy. Failures with the primary field therapy are due mainly to obscure micrometastases outside the primary field. With the treatment modalities currently available, this form of combined-modality therapy appears to offer the best chance to cure patients with solid tumors. Remote micrometastases are usually present in patients with one or more positive lymph nodes at the time of surgery and in patients with tumors with a known propensity for early hematogenous spread. The risk of recurrent or metastatic disease in these patients is extremely high. Only systemic therapy can adequately address micrometastases. Chemotherapies that are at least moderately effective against advanced cancer can have a healing potential when combined with a primary treatment such as surgery. Several studies show that adjuvant chemotherapy prolongs both disease-free survival and overall in patients with osteogenic sarcoma, rhabdomyosarcoma, or breast cancer. Similar comments apply to the use of three cycles of combination chemotherapy before nodal total radiation in stage IIB Hodgkin?s disease. In breast cancer, premenopausal women with node at the time of mastectomy received combination chemotherapy. It was established that several cytotoxic chemotherapy programs achieve lengthening of disease-free survival and overall, this treatment method has increased the cure rate of high-risk primary breast cancer. In general, chemotherapy with at least three active drugs were useful. The results produced by combination chemotherapy are superior to those produced by single agents, because the combination is facing chemotherapy better with the heterogeneity of tumor cells and produces a log greater tumor kill. Full protocol doses of cytotoxic agents are needed to maximize the likelihood of effectiveness. Clinical trials have shown tamoxifen to be an effective adjuvant in women postmenopausal estrogen receptor positive test on the primary tumor. Because it is cytostatic rather than cytotoxic adjuvant treatment with tamoxifen is usually given for 5 years. A recent study in women with node showed no additional benefit with 10 years of tamoxifen therapy. Tamoxifen adjuvant chemotherapy is now standard in node-positive postmenopausal women with ER positive or tests on tumor samples PR. Tamoxifen has also received regulatory approval to reduce the incidence of breast cancer in women who are at high risk of developing the disease.

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Tags: ADJUVANT, cancer, CHEMOTHERAPY, Colorectal, include

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